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GSH, synthesized from glutamate, cysteine and glycine via glutamine cysteine ligase and GSH synthetase, serves as the primary antioxidant in mammalian cells

It complements medications and clinical treatments, making it popular for athletic and post-procedure healing

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Antioxidants are particularly important because they help combat oxidative stress responsible for cellular damage caused by free radicals

This may be along with general COX 1 and COX 2 specificity (24), with the pyloric sphincter less sensitive to COX 2 and the lower esophageal sphincter more sensitive, but ultimately both affected by inhibition of both COX 1 and COX 2

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