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In short you eat carbs, pancreas makes insulin, your liver stops making glucose

doi: 10.1038/nm.3016 67 KruegerJG

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GLP-1R KO can lead to increased appetite, contributing to weight gain.1 GLP-1R is involved in regulating both insulin and glucagon secretion, and its knockout can impair pancreatic function, thereby affecting the balance of these hormones and glucose homeostasis.41,42 GLP-1R is expressed in the cardiovascular system, and its knockout has implications for cardiovascular function.43,44 GLP-1R is present in the CNS, and its absence might contribute to alterations in behavior, mood, or cognitive function.45,46 GLP-1R GLP-1R GPCR , GLP-1

Ontogeny of feeding behavior in the zucker obese rat

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