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Upon activation cues, GSTO1 removes this inhibitory SSG on ASC to enable ASC speck formation and productive inflammasome assembly 68

They are highly beneficial for individuals with significant metabolic disease, such as severe obesity or Type 2 diabetes

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Semaglutide, like any medication, has side effects, and patients may worry if taking it could increase their chances of developing urinary tract infections (UTIs)

This is relevant because hyperuricemia is common in people with obesity and metabolic syndrome, and elevated uric acid is associated with gout and cardiovascular risk