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Within body tissues, the specific B12 binding proteins transcobalamin I and II facilitate the absorption of cyanocobalamin into the cells.1017 Cyanocobalamin is a cofactor for the synthesis of two major enzymes in the body namely methionine synthase and L-methymalonyl-CoA mutase

In fracture models, shortening of bone healing time and improvement of their mechanical strength were observed

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Patients gradually increase their dose over the first 4 weeks, reaching maintenance dosing by week 5

however, evaluation of clinically important primary outcomes has not shown improvement and should be prioritized in future trials

To view a copy of this license, visit About this article Cite this article Pinto, L.C., Falcetta, M.R., Rados, D.V