In trials, retatrutide produced larger average weight loss (about 24.2% at 48 weeks versus roughly 20.9% for tirzepatide at 72 weeks)
In SURMOUNT-1 the pivotal study supporting FDA approval adults without diabetes treated with tirzepatide 15mg lost a mean of 21% of their body weight (approximately 48 lbs) over 72 weeks when combined with a reduced-calorie diet and increased physical activity
Sakamoto M, Tsujikawa H, Effendi K, Ojima H, Harada K, Zen Y, et al
Eli Lilly, the manufacturer of Mounjaro, provides a Savings Card program for eligible participants with commercial insurance in the United States
supply chain, prompting FDA consumer warnings. Disclaimer This article is for educational purposes only and is not a substitute for medical advice
According to the International Diabetes Federation (IDF) in 2021, approximately 537 million adults aged 2079 worldwide have diabetes, which is expected to rise to 783 million by 2045 ( Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two important incretin hormones secreted by the intestine that play a key role in maintaining glucose homeostasis ( 2 Methods 2.1 Literature search Retrieval should be conducted using PubMed, EMBASE, and Sino Med databases