The recommended maintenance dose is 5 mg, 10 mg, or 15 mg once weekly, with a maximum of 15 mg once a week
GLP-1 treatment appears to target key pathways such as IL-17 , which are often over-activated in HS
The crushing fatigue, the unpredictable post-exertional crashes, and the disorienting brain fog are not manifestations of anxiety or a lack of willpower
If you develop fever, spreading redness, or pus at the injection site, seek care promptly to rule out infection
The E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1 serve key roles in skeletal muscle degradation (70)
Its a good choice for the gut health benefits this supplement is designed to impart, as a pair of randomized, double-blind, and placebo-controlled trials in 2019 found that a 10g daily dose of the stuff significantly improved stool frequency in a cohort at increased risk for constipation (ages 4075).29 Other studies, including a 2024 systematic review and meta-analysis, determined that chicory inulin may even help with weight management.30 The issue is that successful studies have used very high doses at least 10g per day, as opposed to the 276mg in Akkermansia so the chicorys role here appears to be exclusively as a food for the bacterial species
