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We have chosen two mutations (Ser441Leu and Arg217Cys) from different hotspot position (regulatory NADH and GTP binding site) with highest frequency of HI/HA mutations according to Stanley et al

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Antioxidants 13:541

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Exenatide is typically prescribed with other drugs, and is used to reduce blood glucose levels amongst patients with type 2 diabetes who cannot achieve stable blood glucose by taking metformin, or metformin in combination with other drugs