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Step 2: Optimal placement

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269 When mechanical stress is applied to the ligament, integrins cluster and recruit focal adhesion proteins, activating intracellular signaling pathways such as the MAPK/ERK and RhoA/ROCK pathways

In summary, STAT3 is not only a central hub in pathological processes but also a key therapeutic target for alleviating disease progression through multiple pathways (e.g., inhibiting oxidative stress and regulating iron metabolism)