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However, lower doses such as 1.0 mg and 1.7 mg also produced significant results, ranging from 9% to 13% weight loss, with fewer patients reporting severe side effects

An adenovirus carrying ferritin light chain/heavy chain and transferrin can up-regulate NF-B/INOS and down-regulate Nrf2/GPX4 in the ovaries of 3-month-old rats, confirming that oxidative stress-inflammatory response is mediated by iron homeostasis disorder in ovarian aging

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Hormones, particularly estrogen, also play a significant role by influencing fat storage and the elasticity of connective tissues