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Our review show that although serum homocysteine and cystathione levels are not significantly different in children with autism spectrum disorders compared to those without, serum cysteine is significantly lower in autistic disorder (Figures 4, 5 and 6) which supports the assertion that cysteine production may be the rate limiting step in glutathione synthesis [3134]

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For example, a mouse model showed a 45% drop in the GSH/GSSG (glutathione disulfide) ratio after just one week of urban air exposure, alongside increased markers of oxidative stress like lipid peroxidation and protein carbonyls

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10.3389/fimmu.2020.551758 Front Immunol

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