however, once the balance between ROS production and clearance is disrupted, excessive ROS generation can lead to heightened oxidative stress (17)
Patients aged 75 years and older (WEGOVY-treated and placebo-treated) reported more serious adverse reactions overall compared to younger adult patients [see Adverse Reactions (6.1)]
Cellular stress responses: cell survival and cell death
COX-2 is an N-glycoprotein with 4 glycosylation sites 33 , and it has been shown that inhibition of COX-2 N-glycosylation by site-directed mutagenesis or pharmacologically using an N-glycosylation inhibitor leads to the production of a COX-2 protein with reduced molecular mass and activity 34
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