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Despite these overlaps there are differences in downstream effects, with IGF-1R preferentially mediating cell growth and InsR preferentially regulating metabolism

Peptone-triggered secretion of GLP-1 from murine primary colonic cultures is also abolished in the presence of CaSR antagonists and removal of extracellular calcium, though whether this effect represents the sensing of individual amino acids generated by initial protein breakdown, or the ability of small peptides to bind to the CaSR is unclear (132)

Revised the manuscript: FJ CLS FM HC TH RC HR

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