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Although the paper does not outline specific criteria for identifying patients who might deteriorate significantly, some combination of dose ingested, time of ingestion, specific form of VPA involved (long-acting preparations pose an increased risk of continued delayed absorption), serum VPA level on presentation, and symptoms should be considered

Under Section 503A and 503B of the FD&C Act, pharmacies can compound medications when the brand-name version is on the FDA drug shortage list

Not suitable for patients with a personal or family history of medullary thyroid carcinoma

The post says some people see significant benefit and good tolerability at 10 mg or lower, and that pushing toward the ceiling without clinical justification may add side-effect burden for no additional gain

It acts to irritate the tissue and infiltrate growth factors that promote healing

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