Abstract 14387: dose-related reductions in blood pressure with a RNA interference (RNAi) therapeutic targeting angiotensinogen in hypertensive patients: interim results from a first-in-human phase 1 study of ALN-AGT01
Some of these mechanisms include the regulation of lipid metabolism in the liver (Nagaoka et al., 2021), the activation of the expression of genes encoding low-density lipoprotein (LDL) receptors in the liver (Udenigwe and Aluko, 2012), the interaction of plant-derived bioactive peptides with bile acids and cholesterol in the gut, and their mediated effects on cholesterol receptors and hormones (Maestri et al., 2016)
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