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How Tirzepatide Works Tirzepatide is the first medication that targets two hormones instead of one: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

This includes taking your dose first thing in the morning on an empty stomach with no more than 4 oz of plain water

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Front Neurosci 14:599646 Meloni A, DeYoung M, Lowe C, Parkes D (2013) GLP-1 receptor activated insulin secretion from pancreatic -cells: mechanism and glucose dependence

Aim for 5-10 minutes of chewing after each meal and whenever dryness becomes particularly bothersome