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It is recommended to prioritize its use in patients with comorbid ASCVD or CKD

The Phase 3 TRIUMPH-4 trial confirmed these results with 23.7% body weight reduction at 12mg and 20.0% at 9mg

In PWA groups, heatmaps displayed a clear separation between PWA + Vehicle and PWA + GLP1/E, indicating substantial alterations in proteomic profiles upon treatment, with both increased and decreased proteins being observed in the treated group (Fig

Adding it to a GLP-1 can produce 2-4% additional loss in some patients, though the data is limited and largely observational

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