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Role of endothelial dysfunction in the development of HFpEF Endothelial dysfunction plays a critical pathophysiological role in heart failure with preserved ejection fraction (HFpEF)

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However, in pathological states, such as during reperfusion, the generation of ROS from the electron transport chain (ETC), particularly complexes I and III, exceeds the normal resulting in leakage of electrons that react with molecular oxygen to form superoxides

TGF-beta and fibrosis in different organs - molecular pathway imprints

Methods Subjects and housing We studied a group of bonobos at Zoo Planckendael (Belgium) (Table 1)

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