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Chronic injury management Chronic injuries that haven't responded to conventional treatment represent another common use case

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However, nucleic acid therapy containing small interfering RNA (He et al., 2014), microRNA, aptamers (Zhou et al., 2016), and immune adjuvant nucleic acids (Zhang et al., 2018), still faces several obstacles: low solubility, instability, weak permeability, uncontrolled drug release kinetics and lack of target specificity

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