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According to the MHRA/EMC Summary of Product Characteristics, the most common adverse effects include: Nausea very common (affects more than 1 in 10 people), often most pronounced when starting treatment or increasing the dose Vomiting very common, typically improves as the body adjusts to the medication Diarrhoea very common Abdominal pain or discomfort common (affects up to 1 in 10 people) Decreased appetite common Constipation common Dyspepsia (indigestion) common, including bloating and flatulence These gastrointestinal effects are generally most prominent during the initial weeks of treatment and often diminish over time as the body adapts

Amplification cycles were: initial denaturation at 94 C for 3 min, followed by 35 cycles of denaturation at 94 C for 30 s, annealing at 55 C for 30 s, and extension at 72 C for 1 min, followed by a final extension at 72 C for 7 min

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