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Abbreviations ACSL1: Acyl-CoA Synthetase Long-Chain Family Member 1 ADRB2: Adrenoceptor Beta 2 AKT: AKT Serine/Threonine Kinase ALT: Alanine Aminotransferase AMPK: Liver Adenosine Monophosphate-Activated Protein Kinase ASK1: Apoptosis Signal-regulating Kinase 1 AST: Aspartate Aminotransferase ATF4: Activating Transcription Factor 4 BCA: Bicinchoninic Acid Assay BCL3: BCL3 Transcription Coactivator BSA: Bovine Serum Albumin BP: BiologicalProcess -arrestin2: Beta-Arrestin 2 CC: CellularComponent cAMP: Cyclic Adenosine Monophosphate CDS: CellDynamicSimulation C/EBP-: CCAAT/Enhancer-Binding Protein Alpha cGAS-STING: cyclic GMP-AMP synthase-stimulator of interferon genes DAMPs: Damage-Associated Molecular Patterns DAPI: 46-Diamidino-2-phenylindole DEGs: Differentially Expressed Genes DNL: De Novo Lipogenesis DT: Decision Tree ECL: Enhanced Chemiluminescence EGR1: Early Growth Response 1 eIF2: eukaryotic Initiation Factor 2 alpha ERK: Extracellular Signal-Regulated Kinase FADD: Fas Associated Via Death Domain FBG: Fasting Blood Glucose FFA: Free Fatty Acids FAS: FAS Cell Surface Death Receptor FOS: AP-1 Transcription Factor Subunit FXR: Farnesoid X Receptor Agonist GF-1: Transforming Growth Factor-beta 1 GBM: GradientBoostingMachine GEO: Gene Expression Omnibus Database Gi: G inhibitory protein GLM: GeneralizedLinearModel GLP-1: Glucagon-Like Peptide-1 Receptor Agonist GLU: Glucose GSDME: Gasdermin E GSH: glutathione GO: Gene Ontology HMGB1: High Mobility Group Box 1 HE: Hematoxylin and Eosin Staining HepG2: Hepatoma Cell Line G2 HSCs: Hepatic Stellate Cells HRP: Horseradish Peroxidase IGT: Impaired Glucose Tolerance IL-1: Interleukin-1 Beta IL-6: Interleukin-6 IF: Immunofluorescence Staining IR: Insulin Resistance JNK: c-Jun N-terminal Kinase KEGG: Kyoto Encyclopedia of Genes and Genomes KNN: K-NearestNeighbors LASSO: LeastAbsoluteShrinkageandSelectionOperator LDL-C: Low-Density Lipoprotein Cholesterol mTOR: Mechanistic Target of Rapamycin mTORC1: Mechanistic Target of Rapamycin Complex 1 MAP3K8: Mitogen-Activated Protein Kinase Kinase Kinase 8 MDA: Malondialdehyde MF: MolecularFunction MyD88: Myeloid Differentiation Primary Response 88 NAFLD: Non-Alcoholic Fatty Liver Disease MASLD: Metabolic dysfunction-associated steatotic liver disease NASH: Non-Alcoholic Steatohepatitis NF-B: Nuclear Factor kappa-light-chain-enhancer of activated B cells NLRP3: NACHT LRR and PYD domains-containing protein 3 NNET: NeuralNetwork OTCC: Optimal Temperature Cutting Compound Pal: palmatine PERK: PKR-like Endoplasmic Reticulum Kinase PI3K: Phosphatidylinositol 3-Kinase PBS: Phosphate Buffered Saline PKA: cAMP-dependent Protein Kinase PDE4: Phosphodiesterase 4 PPAR-: Peroxisome Proliferator-Activated Receptor Gamma PUMA: p53 Upregulated Modulator of Apoptosis PVDF: Polyvinylidene Fluoride RIPA: Radioimmunoprecipitation Assay Buffer ROC: Receiver Operating Characteristic Curve RF: RandomForest SOD: Superoxide Dismutase Sem: Semaglutide Smad3: Mothers Against Decapentaplegic Homolog 3 SREBP-1c: Sterol Regulatory Element-Binding Protein 1c STZ: Streptozotocin ssGSEA: Single-Sample Gene Set Enrichment Analysis SVM: SupportVectorMachine TBA: Total Bile Acids T-C: Total Cholesterol TAK1: TGF--Activated Kinase 1 T-G: Triglycerides TLR4: Toll-Like Receptor 4 TNF-: Tumor Necrosis Factor Alpha T2DM: Type 2 Diabetes Mellitus WB: Western Blot XGB: eXtremeGradientBoosting References Younossi, Z

Lobo RA

doi: 10.1016/j.xcrm.2025.102325, 149 XuQ.SunL.ChenQ.JiaoC.WangY.LiH.et al