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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures

It is not approved or intended for human or animal use, ingestion, dosing, or therapeutic application

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doi: 10.1016/j.pnpbp.2019.03.001

Protein or zinc deficient diets can alter copper metabolism, so a malnourished individual might observe different outcomes than someone with adequate nutrition