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Fibromyalgia affects up to 3% of the general population and is a syndrome characterised by widespread pain, fatigue, sleep disturbances, and cognitive dysfunction, somatic symptoms, and psychiatric disorders [90]

NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

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Note that this source extrapolates from post-bariatric-surgery protocols and hedges its recommendations as measures that may help mitigate symptoms

The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (the diabetes & aging study)