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N Engl J Med 368(17):15751584 Tian G-H, Sun K, Huang P, Zhou C-M, Yao H-J, Huo Z-J, Hao H-F, Yang L, Pan C-S, He K (2013) Long-term stimulation with electroacupuncture at DU20 and ST36 rescues hippocampal neuron through attenuating cerebral blood flow in spontaneously hypertensive rats

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Most patients report reduced appetite within 3-7 days, with noticeable weight loss beginning between weeks 4-8 of consistent dosing

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This dual agonism enhances insulin secretion in a glucose-dependent manner, meaning insulin is released only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia