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This condition, known as hypogonadism, affects about 40% of men over 45 years old (Endocrine Society)

Marsman A, Mandl RC, Klomp DW, Bohlken MM, Boer VO, Andreychenko A, et al

To determine whether reduced JNK activation arises from increased diploidy or from deletion of E2f7/E2f8 , we evaluated pJNK levels in HKO mice following APAP treatment