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Compared with conventional therapy alone, the oral administration of Rhodiola (2.0 grams three times daily for three weeks) significantly reduced serum basic fibroblast growth factor (bFGF) levels and mPAP in HAPH patients

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Furocoumarin derivatives increased the number of skin basal layer melanocytes and melanin-containing hair follicles, and upregulated melanin synthesis and TYR activity by activating cAMP/PKA and MAPK signalling pathways [268]