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Defecation disorder Straining and spending long times in toilet are the main findings in patients with defecation disorder

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Preclinical models demonstrate that region-specific elevations of central KYNA highlight a functional trade-off: while KYNA is often considered neuroprotective due to its antagonism of glutamatergic receptors, its broad receptor profile also allows it to inhibit 7nAChRs, which are essential for prefrontal cortical processing and mood regulation

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Degradation of estrogen receptor in activated blastocysts is associated with implantation in the delayed implantation mouse model