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Nature 395 , 913917 (1998) Armstrong, N

E., Hadigan, C

It is an undesirable side effect of pharmacotherapy, characterized by symptoms such as changes in mental state, autonomic disturbances, or neuromuscular disorders

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An increasing number of evidences, obtained both from humans and animals, suggests that these contaminants are a major risk factor for morbidity and that they cause, in most cases, renal tubular alterations, specifically in the proximal convoluted tubule, and, sometimes, acute renal failure, which may progress to chronic kidney disease

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