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This can sometimes delay the onset of full benefits, and the most substantial weight loss may happen over several months, with ongoing progress as long as the medication and lifestyle changes are continued

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The STEP 8 trial directly compared these two drugs and found that semaglutide achieved 15.8% weight loss compared with 6.4% for liraglutide over 68 weeks

Shared effects include: Nausea Vomiting Diarrhea Constipation Reduced appetite Mild fatigue Clinical trials consistently show mostly mild-to-moderate gastrointestinal side effects with both medications, with nausea being the most commonly reported symptom

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This correlates with DSIP's documented promotion of delta wave (slow-wave) sleep