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Erin, Crowley C

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As demonstrated in Figure 2, in experimental models of CCl4-induced liver injury, GPS administration significantly lowers serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), both of which are critical indicators of hepatic damage ( FIGURE 2 4.4.2 Hepatic antifibrotic mechanisms Liver fibrosis, a prevalent consequence of chronic liver conditions including hepatitis B or C, alcohol-related liver damage, and non-alcoholic fatty liver disease, can escalate to cirrhosisa severe and often irreversible state if not addressed

doi: 10.1093/eurheartj/ehae563 2 KollerDPathakGAWendtFRTyleeDSLeveyDFOverstreetCet al

Melanin cannot be made when these melanin production inhibitors prevent tyrosine from turning into L-DOPA