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We know some safety holes, especially with big, quick weight loss

Hormonal and metabolic adaptation represents another significant factor

These events were generally reported as mild to moderate in severity

Additionally, whilst the glucose-dependent mechanisms of both drugs mean hypoglycaemia risk remains low when used without insulin or sulphonylureas, combining them with other glucose-lowering agents could increase this risk

You should seek urgent medical help if you develop symptoms that may indicate a serious reaction rather than expected treatment adjustment

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