Dosing starts at 0.25 mg per week, increasing gradually to 1 mg2.4 mg per week as tolerated
Mitochondria-targeting drugs include nicotinamide mononucleotide, which supplements the NAD+ pool
However, the exact internalization mechanism remains unclear
Kosiborod MN, Abildstrm SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, Hovingh GK, Kitzman DW, Lindegaard ML, Mller DV, Shah SJ, Treppendahl MB, Verma S, Abhayaratna W, Ahmed FZ, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Merkely B, Nez J, Perna E, Schou M, Senni M, Sharma K, Van der Meer P, von Lewinski D, Wolf D, Petrie MC (2023) Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
Karim, S., Adams, D
10.1016/j.neuron.2007.01.010 Neuron 43 YoungG