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Early GI side effects (nausea, vomiting) peak within 2448 hours of injection in some patients

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This route completely bypasses first-pass metabolism in the liver, a major advantage over drugs that are swallowed and processed through the hepatic portal system

Injection site selection (abdomen, thigh, or upper arm) does not significantly alter absorption rates or overall bioavailability, providing flexibility for patient preference and rotation strategies to minimize injection site reactions

This combination can also increase the risk of alcohol poisoning and worsen side effects, such as increased blood pressure