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Despite the positive outcomes observed in preliminary studies, further research is needed to fully elucidate the mechanisms by which TCM interacts with TMAO and to establish its efficacy in clinical settings

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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound) in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity

The most recent measurements taken prior to the index date were documented as the baseline values for HbA1c and weight

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Higher doses (812 mg weekly) achieved both strong weight reduction and meaningful improvements in HbA1c, fasting glucose, and cardiovascular risk factors