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Differential effect of chronic nicotine administration on brain cytochrome P4501a1/2 and P4502E1

[40] In the 20th century, smoking was common

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A study of 14 healthy volunteers found that serum cortisol was elevated after intake of snus with vs without nicotine, but no postprandial effects were seen on glucose [4]

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The mechanism of action varies between the two medications