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Furthermore this efficacy-to-tolerability ratio appears to be significantly lower for tirzepatide than semaglutide

(2016) 2(10):e1601273

The mean rate of eGFR decline was -1.4 per year in the combined tirzepatide groups and -3.6 per year in the insulin group (between-group difference 2.2 [95% CI 1.6 to 2.8]) with a greater benefit in participants with eGFR 500mg/dl the use of bile acid sequestrants is contraindicated (424)

Patients without diabetic retinopathy

Compare this to semaglutide results showing average losses of 10-15% body weight in clinical trials

The instructional content covered storage, temperature handling, and injection guidance, and the supply set was complete for a first-time injection