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Biased signaling has been hypothesized to confer a therapeutic advantage because -arrestin recruitment can lead to receptor internalization and desensitization, which may dampen a drug's therapeutic effects over time

Take the medication exactly as prescribed by your doctor

Andrew Steen chats with the Chief Medical Officer of Delta Air Lines, who actually put the first AED on a Delta flight in his latest podcast HERE

If considered for the indication of obesity in HFrEF, caution and close monitoring are warranted.

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