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Smoking also increases insulin resistance and damages blood vessels, raising the risk of serious complications such as: Heart attack and stroke Peripheral arterial disease (PAD) Reduced circulation and higher amputation risk While more research is needed on smokings impact on microvascular complications, like kidney, nerve, and eye disease, evidence suggests it may accelerate their progression over time

( 2 ) 3.4 g or more per day of plant stanol esters

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Tissue Damage : The heat and chemicals from cigarette smoke inflict direct damage to throat tissues

doi: 10.4049/jimmunol.180.4.2562