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If the Cys is in a place where it may be reduced by Grx, introduction of the Cys does not have a deleterious effect on protein function because it may be removed

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Grech O, Mitchell JL, Lyons HS, Yiangou A, Thaller M, Tsermoulas G et al (2024) Effect of glucagon like peptide-1 receptor agonist exenatide, used as an intracranial pressure lowering agent, on cognition in idiopathic intracranial hypertension

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We won't list a checklist for you to self-diagnose from, because that's precisely what a proper evaluation is for: we review your labs and history and tell you honestly whether MK-677 fits or whether a different approach serves you better