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This synthetic peptide has become one of the most widely studied compounds in peptide biology due to ongoing research into its interactions with cellular signaling pathways, tissue biology, and gastrointestinal physiology

504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, [online] Volume 10, pp.111

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Note: the 14hr patch is active as soon as applied