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Given that mitochondria are both a primary source of endogenous ROS and a central hub for iron metabolism, their membranes are uniquely vulnerable to ferroptotic insults

B12 deficiency may result from a vegetarian or vegan diet, as B12 naturally occurs in animal foods

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108 A couple of recent double-blind, placebo-controlled, crossover studies using magnetic resonance imaging of the brain also showed significant beneficial changes with acute, single-dose (2400 mg) administration of NAC

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Mild reactions may resolve by discontinuing supplements, while severe symptoms may require medical intervention, such as supportive care or medication