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Furthermore, weight reduction, especially in overweight individuals, can be associated with decreased insulin and inflammatory mediators, which also contributes to improved brain function [187]

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In particular, under hypoxic conditions, Gln consumption is elevated, and Gln carbon is mainly used for fatty acid production through the reductive carboxylation of KG and citrate synthesis [83,84,85], whereas the Gln-derived nitrogen is expelled from cells in the form of dihydroorotate to prevent ammonia-induced toxicity [85]