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the initial stages of non-alcoholic fatty liver (NAFL) can progress to non-alcoholic steatohepatitis (NASH) characterized by persistent inflammatory processes, which in turn can progress to NASH fibrosis [2]

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doi: 10.1523/JNEUROSCI.21-21-08370.2001

Summary and future direction The inability of a medication to cross the BBB to achieve an effective therapeutic concentration in the brain has been the major cause of treatment failure for many brain diseases