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And the extra cushioning typically means less pain

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Specifically, the known surfaces of FBXO22 that interact with BACH1 and BAG3, another known SCF FBXO22 substrate, do not overlap with the region of FBXO22 that contains C326 and engages NSD2 in our structures with either UNC10088 or UNC10415667 13,14,24

Middeldorp et al., 2023)