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Even with just one medication, older people may be especially susceptible to a lack of vitamin B12

Some individuals remain asymptomatic despite ongoing intestinal damage

declares additional funding for this work through the UK Medical Research Council (MRC) (MR/T033371/1), and NIHR Development and Skills Enhancement Award (NIHR301616)

10.1001/jamanetworkopen.2022.31982 [DOI] [PMC free article] [PubMed] [Google Scholar] 18

A: According to FDA prescribing information and clinical trial data, the most common side effects are gastrointestinal: Nausea : 20-44% of users (most common) Diarrhea : ~30% of users Constipation : 24-30% of users Vomiting : 9-24% of users Abdominal pain : 10-20% of users Side effects are typically most intense during first 1-2 weeks at a new dose level and improve significantly by weeks 3-4 at steady dosing

Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative