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Andreeff M , Battula VL, R-Y W, Chen Y, Ling X, Jacamo R, Spaeth E, Konoplev S, Burks J, Hazen A, Schober W, Lu H, Mak D, McQueen T, Shi Y, Tsao T, Zhou L, Ruvolo V, Ruvolo P, Benito J, Borthakur G, Duvvuri S, Klopp A, Mani S, Lang F, Zeng Z, Carter B, Kornblau S, Konopleva M, Marini F

I propose that targeting a single symptom/component of the disease, i.e., a single building block of the PAIS basin of attraction is unlikely to modify its depth enough to give a chance of escaping this attractor

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It systematically summarizes the latest progress of natural metabolites in treating EMS by regulating apoptosis, offering an innovative strategy for treating EMs

showed that in glioblastoma (GBM), BCKAs are heavily mediated by monocarboxylate transporter 1 (MCT 1) and that BCKAs expressed in large quantities are phagocytized and resynthesized into BCAAs by tumor-related macrophages (TAM)