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Some argue that GLP-1RAs may exert neuroprotective effects indirectly via systemic mechanisms, while others suggest that more brain-penetrant incretins might be required for meaningful benefit

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Abbreviations 4-MMP: 4-Methylmorpholine ASBT: Apical sodium bile acid transporter DCC: Dicyclohexylcarbodiimide DOCA: Deoxycholic acid DMEM: Dulbeccos modified Eagles medium DMF: N,N -Dimethylformamide EMCS: 6-Mleimidohexanoic NHS GBSW: Generalized born with simple switching GI: Gastrointestinal GLP-1A: Glucagon-like peptide 1 agonist HBSS: Hanks balanced salt solution IPGTT: Intraperitoneal glucose tolerance test KRBB: KrebsRinger bicarbonate buffer MD: Molecular dynamics MDCK: MadinDarby canine kidney cells PBS: Phosphate-buffered saline PK: Pharmacokinetic References Heller SR, Peyrot M, Oates SK, Taylor AD

It belongs to a class of drugs called glucagon-like peptide-1 receptor agonists, often shortened to GLP-1 RAs

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