Eur J Neurol 24(12):15321538
This independence from the GH-IGF-1 axis is the most scientifically significant property of the compound for experimental design
These are Tremors at rest of hands, legs, and/or jaw Slowness of speed of movements (bradykinesia) Stiffness of limbs (rigidity) Changes in posture, walking or balance difficulties Reduced facial expression (hypomimia) Difficulty in writing Change in voice quality or slurred speech (hypophonia, dysarthria) Difficulty in swallowing food (Dysphagia) Non-Motor Symptoms of PD: They can occur earlier in the disease before motor symptoms emerge and may be present throughout the course of disease
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Note: Avoid freeze-thaw cycles each temperature fluctuation degrades peptide bonds
