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For anyone on these medications, the takeaway is consistent with what physicians have long recommended: a GLP-1 prescription works best as part of a broader, long-term approach to weight management, not a standalone solution

Food supplements are generally safe

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They act on GLP-1 receptors in the pancreas (insulin secretion, glucagon suppression), hypothalamus (appetite suppression via POMC/NPY pathways), gastric smooth muscle (delayed emptying), and peripheral tissues including adipose and immune cells

Although the precise molecular mechanisms remain unclear, it has been proposed that complex II inhibition helps to maintain mitochondrial redox balance and supports mitochondrial energy metabolism

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