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While preclinical models have yielded valuable insights into microglial heterogeneity, many markers defined in rodent systems [e.g., arginase 1 (Arg1) or rodent-specific chitinase-like protein (Ym1)] have limited expression or different regulation in human microglia

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This approach is especially meaningful for those managing chronic conditions, caregiving duties, or other circumstances that make regular travel to clinical sites impractical