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However, during the development of PF, reduced Nrf2 expression is strongly linked to oxidative stress imbalance

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63 The expression of MTHFD2 is closely related to the response of the folate antagonist methotrexate (MTX) and the thymidylate synthase inhibitor pemetrexed

In vitro studies have shown increased collagen I and III gene expression and protein production in fibroblast cultures treated with GHK-Cu, with effects observed across a range of nanomolar to low micromolar concentrations

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